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Some people have extremely sensitive skin and can't tolerate keeping it on all night long.. Retin A is very drying and may cause blistering, swelling or crusting on very sensitive skin.
Many derms after carefully doing a skincription decide the time it should be left-on for. Retin A gets absorbed into the top-most epidermis within 20 mins of application.
Some days are a complete waste of make-up!
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